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. 2017 Nov 22;7(11):170204. doi: 10.1098/rsob.170204

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 13. — Reciprocal regulation of the APC/C and MCC at the SAC. Cartoon illustrating reciprocal regulation of APC/C and MCC by APC/C^MCC. MCC binding to APC/C^Cdc20 generates APC/C^MCC that blocks D-box- and KEN-box-dependent substrate binding. APC/C^MCC interconverts between APC/C^MCC-closed and APC/C^MCC-open, with APC/C^MCC-closed predominating. In APC/C^MCC-open the UbcH10 binding site is exposed. UbcH10 binding to APC/C^MCC-open catalyses Cdc20^MCC auto-ubiquitination. Ube2S elongates Ub-conjugates initiated by UbcH10. Cdc20^MCC ubiquitination promotes disassembly of APC/C^MCC to generate APC/C^Cdc20. APC/C^MCC disassembly may also be mediated by BubR1 ubiquitination. p31^comet and TRIP13 participate in MCC disassembly. During an active SAC, sustained assembly of MCC regenerates APC/C^MCC. (U: ubiquitin, dU: donor ubiquitin). The position of Bub3 within APC/C^MCC is unknown. Adapted from Alfieri et al. [92].