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. 2017 Nov 22;7(11):170204. doi: 10.1098/rsob.170204

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Coactivators interact with Apc1 and Apc3 and create a D-box co-receptor with Apc10. (a) Overview of the APC/C with the Cdh1 coactivator subunit. Based on the APC/C^Cdh1.Emi1 coordinates (PDB 4UI9) [80] with the KEN box and ABBA motif modelled on the S. cerevisiae Cdh1–Acm1 complex (PDB: 4BH6) [71]. Except for the D box, Emi1 coordinates are not shown. (b) Close-up view of the D-box co-receptor formed from Cdh1 and Apc10. (c) Cdk1-dependent phosphorylation of the NTD of Cdh1 blocks its binding to the APC/C. Red spheres indicate sites of inhibitory phosphorylation.