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Degron consensus sequences. (a) Sequence motif of D box derived from 68 APC/C substrates [71]. Sequence motif determined using multiple expectation maximization for motif elicitation (MEME) [116]. (b) Sequence motif of KEN box derived from 46 APC/C substrates [71]. (c) Alignment of consensus D box degron with non-canonical D box degrons. (d) Consensus KEN box. Adapted from [71].
