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. 2017 Nov 22;7(11):170204. doi: 10.1098/rsob.170204

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 9. — Control of APC/C^Cdc20 by phosphorylation. (a) In the unphosphorylated state an auto-inhibitory segment (AI; dark green) within the Apc1^300s loop of Apc1^WD40 mimics the Cdc20 C-box motif and binds to the C-box binding site, blocking Cdc20 association. The AI segment is located on the same face of the APC/C as the hyperphosphorylated Apc3 loop. (b) Zoomed view of the AI segment of Apc1^WD40 associated with the C-box binding site of Apc8B. (c) Superposition of the AI segment with the Cdc20 C box (purple) shows that a conserved Arg residue anchors both the C box and the AI segment to the C-box binding site. Sites of mitotic phosphorylation present within the AI segment that activate APC/C^Cdc20 are depicted as red spheres. From Zhang et al. [60].