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. 2016 Nov 23;61(24):8596–8624. doi: 10.1088/1361-6560/61/24/8596

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© 2016 Institute of Physics and Engineering in Medicine

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Figure 6. — (a) Simulated time-activity curves for tissue with perfused fraction of 50% and three different vascular maps, leading to a range of temporal mean $P_{O_{2}}$ values. Plotted activity is a spatial average over the whole simulation domain, and is attenuation corrected to time of injection. Logarithmic time axis spans 4 h. Peak value of blood activity curve is 63.4 kBq ml⁻¹ and occurs at 11 s. (b) Relative contributions of activity in each compartment of the model to the overall time-activity curve labelled $〈 P_{O_{2}} 〉 = 10$ mmHg in (a). Animations showing the spatial distribution of FMISO in each compartment over time are available in the supplementary material.