Figure A1.

(a) Histograms representing the simulated oxygen partial pressure ($P_{{\mathrm{O}}_2}$) distributions in tissue with three-dimensional vessel maps measuring 1 mm³ and vascular volume fractions of 1% and 5%. Three vessel orientations are examined (parallel, perpendicular and isotropic), and example volume renderings of the vessel maps are inset. Bin heights represent the mean of 20 simulations, and error bars denote  ±1 standard deviation. (b) Histograms representing the simulated FMISO activity distributions in the same 3D volumes as (a), 4 h after injection. Insets show example 2D slices of $P_{{\mathrm{O}}_2}$ (left) and FMISO (right) distributions. Bin heights represent the mean of 20 simulations, and error bars denote  ±1 standard deviation.