Table 1.

Small molecules inhibiting the HSF1-mediated HSR/HPSR. n.d., not determined.

drug-like compounds	chemical class	mechanisms of action	molecular targets	references
quercetin	flavonoid	reduction of HSF1 expression	many	[134,135]
KNK437	benzylidene lactam	blockade of HSF1-mediated HSP transcription	n.d.	[136]
triptolide	diterpenoid epoxide	global transcriptional arrest	XPB/ERCC3	[137,138]
KRIBB11	pyridinediamine	blockade of HSF1-dependent recruitment of P-TEFb to the HSP72 promoter	HSF1 in cell lysates	[139]
fisetin	dietary flavonoid	blockade of HSF1 binding to the HSP72 promoter	n.d.	[140]
NZ28 and emunin	emetine	inhibition of HSP mRNA translation	n.d.	[141]
rohinitib	rocaglate	blockade of genome-wide HSF1 DNA binding	EIF4A	[142]