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. 2017 Dec 1;8:980. doi: 10.3389/fphys.2017.00980

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Copyright © 2017 Mukund and Subramaniam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Drug disease network for 3 disease clusters. (A) shows the number of protein modules associated with each disease cluster considered e.g., 13 protein modules were shared among all clusters, 14 modules were uniquely regulated in the DMD/BMD/LGMD cluster, 30 in the IBM/PM cluster and 42 in the DM/JDM cluster. (B) represents the approved drugs (Table S8) associated with the protein modules uniquely regulated in each disease cluster. Nodes in yellow are drugs currently utilized for treatment in the diseases associated with the cluster. Sirolimus and Ruxolitinib, investigational therapeutics currently used in DM/JDM were also identified within the DM_JDM cluster.