Figure 1.

Magnetic field-dependent lung targeting. (A) Pictorial representation of NIMs dry powder showing lactose (gray), doxorubicin (red), and SPIONs (black).¹⁷ (B) Scanning electron microscope image of NIMs dry powder. (C) Schematic of endotracheal delivery of magnetically-targeted NIMs. (D) Orientation of the permanent magnet in thoracotomized mice prior to pulmonary delivery of NIMs. (E) Orientation of the trachea, right lung, and left lung prior to imaging. SPIONs are visible in the trachea and left lung (shown by arrows) demonstrating magnetic targeting.