Figure 4.

Iron quantification of magnetic targeting and corroboration of iron and dye components from NIMs. Comparison of targeting efficiency (measured as iron concentration, graphed as percent of total) of NIMs dry powder and liquid suspension in left (targeted) and right lungs (untargeted): (A) in the presence and (B) in the absence of magnetic targeting. (C) Comparison of iron targeting efficacy between vehicles in the presence and absence of targeting. Dashed line describes equal iron in left and right lung. Iron above shows targeting to left lung and below shows anti-targeting to right lung. (D) Comparison of fluorescence and iron differentials to the left lung (see eq 3) in the presence and absence of magnetic targeting of NIMs powder and liquid suspension. A two-way ANOVA with Sidak’s multiple comparison test (for A, B, and D) was used to determine statistical significance. *p <.05; **p <.01; ns = not significant; data shown with standard error of the mean (SEM) and n = 3.