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. 2017 Dec 6;36:176. doi: 10.1186/s13046-017-0651-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow diagram of gene expression signature identification and performance assessment. Gene expression profiles were retrieved from the U133A/ U133APlus2 microarray through a bioinformatics approach. Gene expression analyses were performed in the training set (six GEO microarray datasets) first and then validated in TCGA cohort two validation sets (and the FUSCC cohort)