Table 4.

Top 20 enriched pathways of 55 genes within network

Feature ID	Name	Data source	Genes	P Value
WP366	TGF beta Signaling Pathway	WIKIPATHWAYS	APP ATF2 EP300 FOSB HDAC1 MYC PTK2 SP1 TP53	4.97E-07
WP138	Androgen receptor signaling pathway	WIKIPATHWAYS	EP300 HDAC1 KAT5 MDM2 PTK2 RELA SP1	4.27E-06
path:hsa05202	Transcriptional misregulation in cancer	KEGG	CEBPB HDAC1 MDM2 MYC PTK2 RELA SP1 TP53	2.02E-05
WP2377	Integrated Pancreatic Cancer Pathway	WIKIPATHWAYS	APP EGR1 EP300 HNF4A MDM2 MYC SP1 TP53	3.49E-05
path:hsa05169	Epstein-Barr virus infection	KEGG	ATF2 CD44 EP300 HDAC1 MDM2 MYC RELA TP53	4.12E-05
path:hsa05030	Cocaine addiction	KEGG	ATF2 FOSB MAOB RELA SLC18A2	1.33E-04
REACT_169274	Cellular Senescence	REACTOME	CEBPB MDM2 RELA SP1 TERF1 TP53 UBC	3.43E-04
path:hsa05031	Amphetamine addiction	KEGG	ATF2 FOSB HDAC1 MAOB SLC18A2	4.35E-04
REACT_169325	Oncogene Induced Senescence	REACTOME	MDM2 SP1 TP53 UBC	4.68E-04
REACT_120734	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	REACTOME	HDAC1 MYC SP1 UBC	1.00E-03
path:hsa05220	Chronic myeloid leukemia	KEGG	HDAC1 MDM2 MYC RELA TP53	1.00E-03
REACT_120956	Cellular responses to stress	REACTOME	CEBPB EP300 MDM2 RELA SP1 TERF1 TP53 UBC	1.00E-03
WP1984	Integrated Breast Cancer Pathway	WIKIPATHWAYS	EP300 HDAC1 MDM2 MYC SP1 TP53	1.00E-03
WP254	Apoptosis	WIKIPATHWAYS	IGF2 MDM2 MYC RELA TP53	1.00E-03
REACT_121061	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	REACTOME	HDAC1 MYC SP1 UBC	1.00E-03
path:hsa05166	HTLV-I infection	KEGG	ATF2 EGR1 EP300 KAT5 MYC RELA TP53	2.00E-03
WP399	Wnt Signaling Pathway and Pluripotency	WIKIPATHWAYS	CD44 EP300 MMP7 MYC TP53	2.00E-03
REACT_118780	NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	EP300 HDAC1 MYC UBC	2.00E-03
REACT_299	Signaling by NOTCH	REACTOME	EP300 HDAC1 MYC TP53 UBC	3.00E-03
h_arfPathway	Tumor Suppressor Arf Inhibits Ribosomal Biogenesis	BIOCARTA	MDM2 MYC TP53	3.00E-03