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. 2017 Dec 6;8:276. doi: 10.1186/s13287-017-0725-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effect of LXR and Hh signaling on oxysterol-induced PDLSC osteogenesis. Cells pretreated with 22-NHC or transfected with LXRαβ siRNAs before SS (1 μM) treatment. (a) ALP activity. (b) mRNA expression and (c) protein levels of OCN, OSX, and RUNX2. Data obtained from three independent experiments. *P < 0.05 vs control value; ^# P < 0.05 vs SS treatment alone. LXR liver X receptor, NC negative control, 22-NHC 22-azacholesterol, OCN osteocalcin, OSX osterix, RUNX2 Runt-related transcription factor 2, siRNA small interfering RNA, SS 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol