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Effects of Sm 5 mg/kg and saline + DMSO (vehicle) on TNF-α (A), IL-1β (B), CINC-1 (C) and IL-10 (D) in gingival tissues levels. Data represent the mean ± SEM of six animals/group. *P < 0.05 compared with naïve group (control); **P < 0.05 compared with vehicle group (animals submitted to experimental periodontitis and treated with saline + DMSO) (ANOVA and Tukey's post-hoc test).
