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. Author manuscript; available in PMC: 2017 Dec 6.
Published in final edited form as: Cell. 2016 Dec 1;167(6):1469–1480.e12. doi: 10.1016/j.cell.2016.11.018

Figure 6. Microbiome dysbiosis of PD patient samples after transplant into germ-free mice.

Figure 6

(A) Unweighted UniFrac Principle Coordinate Analysis of microbial communities of human donors (large circles) and recipient mice (small circles). Each donor and recipient sample are matched by color.

(B) Unweighted and weighted UniFrac analysis of microbial communities in recipient animals based on donor identity

(C) Unweighted and weighted UniFrac analysis of microbial communities in recipient animals based on mouse genotype

(D) Comparison of unweighted and weighted UniFrac analysis of microbial communities in recipient animals

(E) Taxa-level analysis of individual genera altered between PD and healthy donors as a function of recipient mouse genotype. Left column indicates percentage with significant differences observed; right column indicates fold change between PD and healthy donors. Light colors indicate non-statistically significant differences

N=3-6, over 3 time points post-colonization. ***p≤ 0.001, 999 permutations. HC=germ-free mice colonized with fecal microbes from healthy controls, PD=germ-free mice colonized with fecal microbes from Parkinson's disease patients, WT=wild-type, ASO=Thy1-α-synuclein genotype. See also Figure S6.