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. Author manuscript; available in PMC: 2018 May 10.
Published in final edited form as: Sci Transl Med. 2017 May 10;9(389):eaal2668. doi: 10.1126/scitranslmed.aal2668

Fig. 1. Correlation of MYC expression with ribosomal biogenesis and translation activity.

Fig. 1

(A) Correlation analysis of MYC expression on the y axis and the Z-score enrichment across over 1000 cell lines from the CCLE database. A Z score was generated for each cell line by combining two KEGG canonical pathway gene sets: ribosomal biogenesis and translation. Red dots indicate MM cell lines, and black circles indicate all CCLE cell lines except MM. A significant correlation between MYC expression and the translation activation was observed; R = 0.478, P < 0.0001. Gene Set Enrichment Analysis (GSEA) of MM patient tumor cell-derived gene expression profiling (GSE6477 and GSE16558) shown in (B) and (C), confirming enrichment of translation and ribosomal biogenesis in context of high expression of MYC. ES, enrichment score; FDR, false discovery rate.