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. Author manuscript; available in PMC: 2018 May 10.
Published in final edited form as: Sci Transl Med. 2017 May 10;9(389):eaal2668. doi: 10.1126/scitranslmed.aal2668

Fig. 6. Pathway analysis of CMLD010509.

Fig. 6

(A) Network enrichment analysis of 54 depleted proteins with more than twofold change analyzed in the KEGG database, showing that cancer pathways were highly enriched among these depleted proteins. AML, acute myeloid leukemia; CML, chronic myeloid leukemia; MAPK, mitogen-activated protein kinase; JAK/STAT, Janus kinase/signal transducer and activator of transcription. (B) The 54 depleted proteins were queried against MSigDB C2 canonical pathway database, showing an enrichment of MM specific oncoproteins including IRF4 pathway. (C) Z scores of the 54 proteins evaluated on 1000 cell lines of the CCLE database. (D) Z scores of the 54 proteins evaluated on two independent gene expression profiles including patients at diagnosis (GSE16558) and at relapse (GSE6477).