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. 2017 Dec 6;36:175. doi: 10.1186/s13046-017-0646-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — FOXA1 directly inhibits PIK3R1 transcription. FOXA1 directly binds to the PIK3R1 promoter sequence (a) and suppresses PIK3R1 transcription (b). Knockdown of PI3Kp85 reverses the increase in cell proliferation induced by downregulation of FOXA1 (c-e) (EdU magnification ×400)