Table 3.
Clinical and biochemical characteristics in normotensive controls and subgroups of hypertension patients according to EPHA6 genotype
| EPHA6 | Normotensive controls (n = 1605) | Hypertension group (n = 541) | ||||
|---|---|---|---|---|---|---|
| CC (n = 446) | CT allele (n = 829) | TT (n = 330) | CC (n = 135) | CT allele (n = 261) | TT (n = 145) | |
| Age (year) | 47.9 ± 10.9 | 48.4 ± 10.8 | 47.4 ± 11.3 | 54.6 ± 11.1 | 54.8 ± 11.8 | 53.1 ± 11.8 |
| Weight (kg) | 63.4 ± 9.98 | 62.7 ± 10.3 | 63.4 ± 10.6 | 66.8 ± 11.3 | 68.7 ± 12.2 | 68.1 ± 11.7 |
| BMI (kg/m2) | 23.8 ± 2.89 | 23.7 ± 2.94 | 23.8 ± 2.87 | 25.0 ± 3.21 | 25.5 ± 3.23 | 25.5 ± 3.14 |
| Waist (cm) | 83.6 ± 7.75 | 83.4 ± 7.84 | 83.6 ± 7.71 | 87.0 ± 8.76 | 88.1 ± 8.79 | 88.1 ± 8.48 |
| Waist hip ratio | 0.88 ± 0.06 | 0.88 ± 0.06 | 0.89 ± 0.06 | 0.90 ± 0.06 | 0.90 ± 0.05 | 0.91 ± 0.07 |
| Systolic BP (mmHg) | 114.5 ± 11.5b | 117.0 ± 11.5a | 117.4 ± 11.2a | 136.4 ± 15.9b | 138.0 ± 14.6a,b | 141.3 ± 15.9a |
| Diastolic BP (mmHg) | 71.7 ± 8.67b | 73.0 ± 8.63a | 73.1 ± 8.95a,b | 86.5 ± 11.0 | 87.2 ± 10.6 | 88.7 ± 10.3 |
| Triglyceride (mg/dL)∮ | 115.4 ± 64.3 | 122.3 ± 77.8 | 119.1 ± 75.9 | 144.5 ± 79.5a,b | 141.2 ± 78.7b | 165.0 ± 106.2a |
| Total cholesterol (mg/dL)∮ | 200.0 ± 37.3 | 197.2 ± 36.2 | 197.4 ± 33.8 | 196.0 ± 33.7 | 198.5 ± 38.5 | 200.0 ± 33.2 |
| HDL cholesterol (mg/dL)∮ | 54.2 ± 12.8 | 53.7 ± 13.9 | 54.0 ± 13.6 | 51.0 ± 12.8 | 50.8 ± 13.4 | 49.1 ± 11.7 |
| LDL cholesterol (mg/dL)∮ | 122.9 ± 33.3 | 120.1 ± 33.1 | 120.7 ± 30.6 | 116.2 ± 29.2 | 120.1 ± 35.3 | 120.1 ± 31.0 |
| Apolipoprotein A-I (mg/dL)∮ | 157.3 ± 26.3 | 155.9 ± 29.6 | 155.0 ± 27.1 | 154.1 ± 25.6 | 155.8 ± 30.2 | 156.1 ± 25.6 |
| Apolipoprotein B (mg/dL)∮ | 107.6 ± 29.3 | 103.3 ± 29.4 | 102.9 ± 28.6 | 100.8 ± 27.2b | 103.2 ± 28.6b | 110.6 ± 25.9a |
| Glucose (mg/dL)∮ | 95.0 ± 20.1 | 95.7 ± 19.7 | 96.4 ± 23.7 | 104.4 ± 23.9 | 104.0 ± 27.6 | 103.5 ± 24.5 |
| Insulin (μIU/dL)∮ | 9.32 ± 4.91 | 8.97 ± 4.64 | 9.04 ± 4.32 | 8.99 ± 4.33 | 10.1 ± 6.39 | 10.2 ± 5.67 |
| HOMA-IR∮ | 2.18 ± 1.24 | 2.13 ± 1.35 | 2.15 ± 1.17 | 2.30 ± 1.32 | 2.63 ± 2.42 | 2.63 ± 1.77 |
| LDL particle size (nm)∮ | 24.0 ± 0.81 | 23.9 ± 1.27 | 24.0 ± 0.77 | 24.0 ± 0.94b | 24.0 ± 0.66b | 23.5 ± 0.85a |
Mean ± SD. ∮tested by logarithmic transformation. P-values derived from a One-way ANOVA. All alphabetical P < 0.05 derived from Bonferroni post hoc tests; no significant differences are marked with the same alphabet and significant differences are marked with a different alphabet