Table 2.
Relationship between overexpression of Cullin7 and clinico-pathological parameters in HCC
| Parameter | n | Cullin7 | ||
|---|---|---|---|---|
| negative(%) | positive(%) | P | ||
| Sex | ||||
| Male | 144 | 44(30.6) | 100(69.4) | 0.810 |
| Female | 18 | 6(33.3) | 12(66.7) | |
| Age(years) | ||||
| <50 | 97 | 32(33.0) | 65(67.0) | 0.474 |
| ≥ 50 | 65 | 18(27.7) | 47(72.3) | |
| Tumor size(cm) | ||||
| <5 | 90 | 29(32.2) | 61(67.8) | 0.676 |
| ≥ 5 | 72 | 21(29.2) | 51(70.8) | |
| Tumor numbers | ||||
| Single | 116 | 34(29.3) | 82(70.7) | 0.497 |
| multitude | 46 | 16(34.8) | 30(65.2) | |
| AFP(μg/L) | ||||
| <400 | 98 | 31(31.6) | 67(68.4) | 0.793 |
| ≥ 400 | 64 | 19(29.7) | 45(70.3) | |
| HBsAg | ||||
| positive | 135 | 41(30.4) | 94(69.6) | 0.761 |
| negative | 27 | 9(33.3) | 18(66.7) | |
| Tumor thrombus | ||||
| have | 69 | 11(15.9) | 58(84.1) | 0.000 |
| no | 93 | 39(41.9) | 54(58.1) | |
| Lymph metastasis | ||||
| have | 33 | 5(15.2) | 28(84.8) | 0.029 |
| no | 129 | 45(34.9) | 84(65.1) | |
| Pathological grade | ||||
| high | 37 | 12(32.4) | 25(67.6) | 0.780 |
| moderately | 112 | 33(29.5) | 79(70.5) | |
| low | 13 | 5(38.5) | 8(61.5) | |
| Hepatic function | ||||
| Child A | 106 | 34(32.1) | 72(67.9) | 0.820 |
| Child B | 36 | 11(30.6) | 25(69.4) | |
| Child C | 20 | 5(25.0) | 15(75.0) | |
| Clinical stage | ||||
| A | 64 | 30(46.9) | 34(53.1) | 0.001 |
| B | 11 | 5(45.5) | 6(54.5) | |
| C | 67 | 12(17.9) | 55(82.1) | |
| D | 20 | 3(15.0) | 17(85.0) | |