Table 1.
Aβ ELISA Showed a Significant Decrease of Guanidine-Extracted Aβ42 in the Combination AAV1-mIL-6 + Dox Group versus Control Groups
| Aβ species | Pretreated | Untreated | mIL-6 only | Dox only | mIL-6 + dox |
|---|---|---|---|---|---|
| Aβ42, pmol/g | 2301 ± 302 | 4973 ± 402 | 4327 ± 394 | 3947 ± 280 | 2764 ± 377∗ |
| Aβ40, pmol/g | 2094 ± 285 | 3773 ± 362 | 3628 ± 275 | 2668 ± 257 | 2325 ± 299 |
Data are expressed as means ± SEM.
AAV1-mIL-6, adeno-associated virus 1 expressing murine IL-6; Dox, doxycycline; ELISA, enzyme-linked immunosorbent assay.
P < 0.05.