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. 2017 Dec;187(12):2895–2911. doi: 10.1016/j.ajpath.2017.08.006

Figure 5.

Figure 5

CXCL5 genetic association with coronary artery disease (CAD) in additional cohorts. A and C: Contingency plot and P values of CAD status and the minor allele of rs394408 in phase 1 (S1) or phase 2 (S2) of Supporting a Multidisciplinary Approach to Researching Atherosclerosis (SAMARA; A) or in the combined SAMARA cohort (C). B and D: Expression quantitative trait loci analysis of the single-nucleotide polymorphism rs394408 with the number of subjects, genotype, and relative CXCL5 expression levels from either phase 1 of SAMARA (B) or the combined SAMARA cohort (D), represented by box plots (5% to 95% CI) with outliers identified (open circles). The P value and β coefficient of the linear regression are noted. E and F: Plasma levels of CXCL5 represented by dot plot and summarized by the means and 95% CIs of the log values (pg/mL). E: Phase 1 (left), phase 2 (middle), or combined (right) SAMARA subjects were stratified by obstructive CAD status. F: Plasma levels of CXCL5 in subjects with increasing CAD severity, with the corresponding P value of the logistic regression analysis. D–F: The combined data sets used the z-scores of relative CXCL5 expression within each cohort. ∗P < 0.05, ∗∗P < 0.01 versus the decreased CXCL5 levels in subjects with obstructive CAD (t-test).