Table 2.
Regression Analysis of Plasma CXCL5 Levels and CAD Score
| Analyte | P value | OR (95% CI) | Reciprocal OR | CAD Class 0–4 |
|---|---|---|---|---|
| Ordinal | ||||
| CXCL5 unit odds | 0.0013 | 0.52 (0.36–0.78) | 1.91 | 1570, 1638, 1048, 1324, 886 |
| Adjusted model | ||||
| CXCL5 unit odds adj | 0.0148 | 0.59 (0.39–0.90) | 1.69 | |
| Prior statin use (Y) adj | 0.0023 | 1.75 (1.15–2.67) | 5%, 19%, 25%, 21%, 31% | |
| Sex (M) adj | 0.0003 | 1.78 (1.27–2.48) | 7%, 17%, 18%, 24%, 33% | |
| Analyte | P | OR (95% CI) | Recip | Obstructive CAD-no | Obstructive CAD-yes |
|---|---|---|---|---|---|
| Nominal | |||||
| CXCL5 unit odds | 0.0014 | 0.46 (0.27–0.75) | 2.15 | 1638 (1439) | 998 (943) |
| CXCL5 range odds | 0.03 (3.2E-3–0.30) | 32.06 | |||
| Adjusted model | |||||
| CXCL5 unit odds adj | 0.0309 | 0.54 (0.31–0.96) | 1.84 | ||
| CXCL5 range odds adj | 0.06 (4.7E-3 - 0.84) | 57.33 | |||
| Prior statin usage (Y) adj | 0.0100 | 4.02 (1.39–11.58) | 46% | 80% | |
| Sex (M) adj | 0.0140 | 3.03 (1.25–7.33) | 36% | 61% | |
We measured the associations between each CXCL5 and CAD score using nominal and ordinal logistic regression. The adj model controlled for sex, statin use, hypertension, hyperlipidemia, obesity, self-reported race, smoking status, and diabetes. The P value of the effect likelihood test for each analyte in the model at P < 0.05 and the OR (95% CI) are provided. The reciprocal OR is provided for ratios <1. Summary CXCL5 data are presented as median (interquartile range), with units of pg/mL or percentage of subjects in the indicated category for statin use and sex.
M, male; Adj, adjusted model; CAD, coronary artery disease; OR, odds ratio; Y, yes.