Table 3.
Regression Analysis of Plasma Inflammatory Biomarker Levels and CAD Score
| Analyte | P value | OR (95% CI) | CAD Class 0–4 |
|---|---|---|---|
| Ordinal | |||
| MCP1 | 0.706 | 0.90 (0.51–1.59) | 106, 125, 132, 127, 109 |
| MCP1 adj | 0.586 | 0.99 (0.54–1.84) | |
| hsCRP | 0.105 | 1.04 (0.99–1.09) | 4.9, 4.4, 4.3, 5.8, 8.1 |
| hsCRP adj∗ | 0.021 | 1.06 (1.01–1.12) | |
| hsCRPmed [1] | 0.137 | 1.55 (0.87–2.80) | 11%, 20%, 18%, 21%, 30% [1] |
| hsCRPmed adj [1] | 0.097 | 1.68 (1.59–1.76) | 14%, 25%, 25%, 15%, 21% [0] |
| CAM score | 0.285 | 1.08 (0.94–1.23) | −0.12, −0.07, −0.044, 0.60, −0.16 |
| CAM score adj | 0.548 | 1.04 (0.91–1.20) |
| Analyte | P | OR (95% CI) | Obstructive CAD-no | Obstructive CAD-yes |
|---|---|---|---|---|
| Nominal | ||||
| MCP1 unit | 0.661 | 1.16 (0.59–2.29) | 115 (46) | 122 (58) |
| MCP1 range | 1.77 (0.14–22.5) | |||
| MCP1 unit adj | 0.521 | 1.30 (0.59–2.87) | ||
| MCP1 range adj | 2.68 (0.13–54.5) | |||
| hsCRP unit | 0.212 | 1.04 (0.98–1.10) | 4.6 (13.8) | 5.7 (13.1) |
| hsCRP range | 1.72 (0.73–4.04) | |||
| hsCRP unit adj | 0.083 | 1.06 (0.99–1.14) | ||
| hsCRP range adj | 2.41 (0.88–6.63) | |||
| hsCRPmed [1] | 0.321 | 1.42 (0.71–2.85) | 15%/20% [1/0] | 34%/31% [1/0] |
| hsCRPmed adj [1] | 0.201 | 1.69 (0.75–3.80) | ||
| CAM score unit | 0.485 | 1.06 (0.90–1.25) | −0.07 (2.86) | 0.10 (2.68) |
| CAM score range | 1.92 (0.90–1.25) | |||
| CAM score unit adj | 0.665 | 1.04 (0.87–1.25) | ||
| CAM score range adj | 1.58 (0.20–12.6) |
We measured the associations between each analyte and CAD score using nominal and ordinal logistic regression. The adj model controlled for sex, statin use, hypertension, hyperlipidemia, obesity, self-reported race, smoking status, and diabetes. In addition, for hsCRP, the data were stratified higher than [1] or lower than [0] hsCRPmed. The P value of the effect likelihood test for each analyte and the OR (95% CI) are provided. Summary data for continuous variables are presented as the median value from each CAD class for ordinal classification of CAD or as the median (interquartile range) for nominal classification of CAD, with units of pg/mL and mg/L for MCP-1 and hsCRP, respectively, or the median CAM score (normalized distribution value). For hsCRPmed, summary data are presented as the percentage of subjects higher [1] or lower [0] than the median value for the indicated CAD class.
Adj, adjusted model; CAD, coronary artery disease; CAM, cellular adhesion molecule; hsCRP, high-sensitivity C-reactive protein; hsCRPmed, median hsCRP; MCP, monocyte chemoattractant protein; OR, odds ratio.
P < 0.05.