Table 6.
Local Cis eQTL Identified in CAD Genes
| rs Identification | Gene symbol | Gene description | P value | FDR, % | β Value |
|---|---|---|---|---|---|
| rs12708952 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 3 × 10−7 | 0.1 | −0.52 |
| rs4402561 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 4 × 10−7 | 0.1 | 0.49 |
| rs1891241 | LGALS8 | Lectin, galactoside-binding, soluble, 8 | 2 × 10−6 | 0.4 | −0.33 |
| rs1796415 | RNF10 | Ring finger protein 10 | 4 × 10−6 | 0.8 | 0.60 |
| rs10158939 | RP11-553N16.1∗ | Known processed pseudogene | 5 × 10−6 | 0.9 | −0.24 |
| rs11254468 | VIM | Vimentin | 7 × 10−6 | 1.3 | 0.43 |
| rs6599244 | RPL18AP7∗ | Ribosomal protein L18a pseudogene 7 | 1 × 10−5 | 1.9 | 0.44 |
| rs9511357 | ZMYM5 | Zinc finger, MYM-type 5 | 1 × 10−5 | 2.2 | −0.18 |
| rs831757 | ARL8A | ADP-ribosylation factor-like 8A | 2 × 10−5 | 2.5 | −0.23 |
| rs2799428 | LGALS8 | Lectin, galactoside-binding, soluble, 8 | 2 × 10−5 | 2.8 | −0.29 |
| rs244836 | COTL1 | Coactosin-like F-actin binding protein 1 | 2 × 10−5 | 2.9 | 0.23 |
| rs1583585 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 2 × 10−5 | 3.2 | −0.41 |
| rs1963773 | RNF10 | Ring finger protein 10 | 2 × 10−5 | 3.4 | −0.45 |
| rs41416850 | RNF10 | Ring finger protein 10 | 2 × 10−5 | 3.4 | −0.63 |
| rs2737706 | LGALS8 | Lectin, galactoside-binding, soluble, 8 | 3 × 10−5 | 3.7 | 0.30 |
| rs1583587 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 3 × 10−5 | 3.9 | 0.42 |
| rs3779647 | GSR | Glutathione reductase | 3 × 10−5 | 4.0 | −0.19 |
| rs913863 | RRAGC | Ras-related GTP binding C | 4 × 10−5 | 4.8 | −0.10 |
| rs11646643 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 5 × 10−05 | 6.0 | −0.41 |
| rs9989481 | UBALD2 | UBA-like domain containing 2 | 6 × 10−5 | 6.3 | 0.24 |
| rs11206237 | TALDO1 | Transaldolase 1 | 6 × 10−5 | 6.8 | −0.44 |
| rs913863 | RRAGC | Ras-related GTP binding C | 7 × 10−5 | 7.3 | −0.10 |
| rs1477017 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 7 × 10−5 | 7.6 | 0.40 |
| rs1799917 | LPCAT2 | Lysophosphatidylcholine acyltransferase 2 | 7 × 10−5 | 7.6 | 0.41 |
| rs2715143 | GRB10 | Growth factor receptor-bound protein 10 | 7 × 10−5 | 7.6 | −0.84 |
| rs9553323 | ZMYM5 | Zinc finger, MYM-type 5 | 7 × 10−5 | 7.7 | −0.17 |
| rs4415303 | GYG1P1∗ | Glycogenin 1 pseudogene 1 | 8 × 10−5 | 7.8 | 0.49 |
| rs1611699 | HLA-K∗ | Major histocompatibility complex, class I, K | 9 × 10−5 | 8.5 | −0.18 |
| rs3013777 | YIPF1 | Yip1 domain family, member 1 | 1 × 10−4 | 9.5 | −0.21 |
| rs11185517 | NCBP2-AS2 | NCBP2 antisense RNA 2 (head to head) | 1 × 10−4 | 9.7 | 0.16 |
The single-nucleotide polymorphism identifier (rs identification), official gene symbol and description, and the P values, FDRs, and β values from the linear model are provided.
CAD, coronary artery disease; eQTL, expression quantitative trait loci; FDR, false-discovery rate; HLA, human leukocyte antigen; MYM, myeloproliferative and mental retardation motif; NCBP, Nuclear Cap Binding Protein Subunit; UBA, ubiquitin-associated domain; Yip, Ypt-interacting proteins.
∗
Gene symbols and descriptions updated in BioMart that were not initially annotated.