Supplemental Figure S1.

Thoracic radiographs at euthanasia. A–D: Exemplary thoracic radiographs of three MtbΔsigH-vaccinated animals (A–C) in comparison to a Mtb/simian immunodeficiency virus (SIV)-co-infected animal (D) at the time of euthanasia, demonstrating a lack of pulmonary pathology. E: Quantitative analysis of radiographs scored in a single-blind fashion by a board-certified veterinarian (D.N.L.), on the following scale: 0 (null) to 4 (severe lung involvement). ^∗∗P < 0.01 using a t-test analyzing the mean values of all vaccinated animals versus Mtb/SIV–co-infected animals. R, lead marker used for identify right on the radiograph.