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. 2017 Dec;187(12):2841–2857. doi: 10.1016/j.ajpath.2017.08.025

Figure 3.

Figure 3

Immune complex deposition and complement activation in both Tg44 and human polypoidal choroidal vasculopathy (PCV) lesions. IgG (A–C) and IgM (D–F) staining in the choroidal vessel wall of wild-type (WT) and Tg44 PCV lesions (C and F). White arrows indicated strong signals in severe PCV lesions, and yellow arrowheads indicated weak signals in weak PCV lesions (B and E). C3 (G–I) and membrane attack complex (MAC; Sc5b9) (J–L) staining in the choroidal vessel wall of WT and Tg44 PCV lesions. White arrows indicated signals in severe PCV lesions, and white arrowheads indicated signals in weak PCV lesions. No signal was detected in WT. IgG (M and N), IgM (O and P), C3 (Q and R), and MAC (S and T) staining in the choroidal vessel wall of human PCV lesions. White arrows indicated strong signals in lesions (N, P, R, and T). Nuclei were counterstained with DAPI (blue). Scale bars = 10 μm (A–T).