Table 2.
Instrument Scores at Day 1 and Week 12 for RA-BEAM and RA-BUILD
| Instrument | RA-BEAMa | RA-BUILDb | ||
|---|---|---|---|---|
| Day 1 | Week 12 | Day 1 | Week 12 | |
| Severity of Worst Tiredness, Mean (SD) | 5.8 (2.1) | 4.0 (2.3) | 6.0 (2.1) | 4.1 (2.4) |
| Duration of MJS, Mean (SD) | 152.8 (180.8) | 96.7 (144.7) | 160.7 (174.8) | 103.5 (147.5) |
| Severity of MJS, Mean (SD) | 5.8 (2.2) | 3.5 (2.4) | 5.7 (2.1) | 3.7 (2.4) |
| Severity of Worst Joint Pain, Mean (SD) | 6.1 (2.0) | 4.0 (2.3) | 6.0 (2.1) | 4.2 (2.4) |
| Patient’s Assessment of Pain, Mean (SD) | 60.8 (22.3) | 34.9 (24.1) | 58.0 (22.1) | 36.5 (24.9) |
| PtGA, Mean (SD) | 62.4 (21.8) | 36.3 (23.5) | 60.7 (21.1) | 37.7 (24.0) |
| SF-36 | ||||
| Role Physical Domain, Mean (SD) | 35.5 (10.4) | 41.8 (10.2) | 35.3 (9.2) | 40.7 (9.6) |
| Bodily Pain Domain, Mean (SD) | 34.7 (7.8) | 42.5 (8.7) | 34.9 (7.6) | 41.9 (9.0) |
| General Health Domain, Mean (SD) | 36.8 (8.5) | 41.6 (8.9) | 36.8 (8.3) | 42.0 (9.4) |
| Social Functioning Domain, Mean (SD) | 40.8 (11.6) | 45.4 (10.5) | 40.2 (11.2) | 44.7 (10.3) |
| Vitality Domain, Mean (SD) | 43.7 (10.0) | 49.4 (9.8) | 41.9 (10.1) | 48.4 (10.0) |
| Role Emotional Domain, Mean (SD) | 41.1 (12.6) | 45.5 (10.9) | 40.9 (12.3) | 44.8 (11.2) |
| Mental Health Domain, Mean (SD) | 43.0 (11.3) | 47.1 (10.7) | 42.9 (11.6) | 47.1 (11.3) |
| Physical Functioning Domain, Mean (SD) | 32.2 (10.4) | 38.7 (10.9) | 32.2 (10.2) | 38.2 (10.9) |
| Mental Component Score, Mean (SD) | 46.4 (11.8) | 49.8 (10.8) | 45.7 (11.8) | 49.3 (11.1) |
| Physical Component Score, Mean (SD) | 32.3 (8.6) | 39.4 (9.3) | 32.3 (8.3) | 38.8 (9.4) |
| FACIT-F Total Score, Mean (SD) | 28.2 (10.9) | 36.8 (9.6) | 26.8 (11.2) | 35.5 (10.1) |
| QIDS-SR16 Total Score, Mean (SD) | 8.0 (5.0) | 5.9 (4.2) | 8.4 (4.9) | 6.2 (4.3) |
| HAQ-DI Total Score, Mean (SD) | 1.56 (0.68) | 1.03 (0.70) | 1.52 (0.61) | 1.03 (0.66) |
| PhGA, Mean (SD) | 65.0 (16.9) | 31.0 (21.7) | 63.5 (17.4) | 33.9 (22.4) |
| CDAI, Mean (SD) | 37.83 (12.55) | 18.68 (13.54) | 36.05 (12.12) | 18.04 (13.15) |
| DAS28-ESR, Mean (SD) | 6.43 (0.97) | 4.62 (1.46) | 6.22 (0.97) | 4.50 (1.37) |
| DAS28-hsCRP, Mean (SD) | 5.73 (0.94) | 3.93 (1.39) | 5.55 (0.91) | 3.84 (1.35) |
Abbreviations: CDAI = Clinical Disease Activity Index; DAS28 = Disease Activity Score modified to include the 28 diarthrodial joint count; ESR = erythrocyte sedimentation rate; FACIT-F = Functional Assessment of Chronic Illness Therapy-Fatigue; HAQ-DI = Health Assessment Questionnaire-Disability Index; hsCRP = high-sensitivity C-reactive protein; n = number of patients; MJS = morning joint stiffness; PhGA = Physician’s Global Assessment of Disease Activity; PtGA = Patient’s Global Assessment of Disease Activity; QIDS-SR16 = Quick Inventory of Depressive Symptomatology Self-Rated-16; SD = standard deviation; SF-36 = 36-Item Short Form Health Survey version 2 with Acute recall
aDaily diary responses were n = 537(Day 1) and n = 1281 (Week 12); nondiary assessments had approximately n = 1301 (Day 1) and n = 1250 (Week 12)
bDaily diary responses were n = 310 (Day 1) and n = 666 (Week 12); nondiary assessments had approximately n = 680 (Day 1) and n = 644 (Week 12)