Table 5.

Known-Groups Validity of Severity of Worst Tiredness Using DAS28-ESR Subgroups at Day 1 and Week 4

PRO/Study	DAS28-ESR Category		p-value
	≤5.1 N, Mean (SD)	>5.1 N, Mean (SD)
Severity of Worst Tiredness Day 1
RA-BEAM	39, 4.7 (2.6)	496, 5.9 (2.1)	0.001a
RA-BUILD	36, 5.0, (1.9)	273, 6.2 (2.0)	0.002a
Severity of Worst Tiredness Week 4
RA-BEAM	619, 3.6 (2.1)	587, 5.3 (1.9)	0.001a
RA-BUILD	327, 3.7 (2.0)	286, 5.5 (2.0)	0.001a

Abbreviations: DAS28 = Disease Activity Score modified to include the 28 diarthrodial joint count; ESR = erythrocyte sedimentation rate; SD = standard deviation;

^a p-value based on a comparison of mean values using ANOVA