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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Immunobiology. 2017 May 16;222(8-9):900–912. doi: 10.1016/j.imbio.2017.05.011

Table 2.

Effects of CD163 and its antibody reversal effects in macrophage cytokines

Cytokines
-THP-1, LPSx1		 Effect of pCD163 Reversal effect of anti-CD163
TNF-α ↓ (−)
MCP-1 ↓ (−)
Cytokines
-THP-1, LPSx2		 Effect of pCD163 Reversal effect of anti-CD163
IL-10 ↑ (+)
IL-1ra ↑ (+)
MCP-1 ↓ (−)
Cytokines
-Primary Macrophages		 Effect of pCD163 Reversal effect of anti-CD163
IL-10 ↓ (−)
TNF-α ↓ (−)
IL-1β ↓ (−)
IL-6 ↓ (+)

Note: LPSx1 = LPS single stimulation paradigm, LPSx2 = LPS double stimulation paradigm, ↑ = Significant increase expression, ↓ = Significant decrease expression, (−) = No significant reversal effect, (+) = Significant positive reversal effect. The effect of pCD163 is in relation to pEmpty. The reversal effect of anti-CD163 antibody is in relation to pCD163.