TABLE 3.

Severe (grade ≥3) Hematologic and Nonhematologic Events Occurring in 5% or More of Patients (n = 26 Patients)

	Grade
	3		4		5		Total
Adverse Event	N	%	N	%	N	%	N	%
Thrombocytopenia	15	57.7	5	19.2	—	—	20	76.9
Neutropenia	3	11.5	7	26.9	—	—	11*	42.3
Leukopenia	2	7.7	5	19.2	—	—	7	26.9
Anemia	6	23.1	1	3.8	—	—	7	26.9
Transfusion-pRBc	4	15.4	—	—	—	—	4	15.4
Dyspnea	3	11.5	—	—	—	—	3	11.5
Hypotension	1	3.8	2	7.7	—	—	3	11.5
Hypoxia	3	11.5	—	—	—	—	3	11.5
Vomiting	2	7.7	1	3.8	—	—	3	11.5
Diarrhea—no colostomy	3	11.5	—	—	—	—	3	11.5
Infection–ANC	—	—	—	—	3	11.5	3	11.5
Nausea	2	7.7	—	—	—	—	2	7.7
Neuromotor	2	7.7	—	—	—	—	2	7.7
Edema	—	—	2	7.7	—	—	2	7.7
Transfusion–PLT	2	7.7	—	—	—	—	2	7.7
Febrile neutropenia	2	7.7	—	—	—	—	2	7.7

^*Includes 1 patient with undefined neutropenia who were nonetheless recorded as having neutropenic fever which by definition requires an ANC <1000.

All adverse events included regardless of perceived relationship to study treatment.