Table 2.

Fraction of patients with biomarker levels above the reference limit.

			High Sensitivity Biomarkers (% Patients > 99%-tile RL)					Standard Biomarkers (% Patients Exceeded RL)
		Mean (SD) Age	IL-6	cTnI	TNF-α	IL-17A	ET-1	NTproBNP	Leptin	HDL	hsCRP	HbA1c
All Patients		58 (15)	4.8	6.7	9.6	1.5	6.8	15.7	8.8	12.7	24.4	24.0
Patients Grouped by Plasma Testosterone Level (ng/dL)	<200	60 (15)	10.9	9.7	14.5	2.5	15.6	23.8	27.3	23.0	47.4	41.0
	200–299	57 (14)	6.2	6.7	11.8	1.8	7.2	15.4	16.2	20.0	34.6	37.9
	300–399	57 (15)	4.8	6.4	9.0	1.5	6.5	15.6	9.4	13.5	26.8	27.4
	400–499	58 (14)	3.6	6.6	7.7	1.2	5.4	15.8	5.7	8.7	20.1	19.0
	500–599	58 (15)	4.2	6.2	8.9	1.5	7.5	14.2	3.5	8.1	16.5	17.3
	600–699	58 (15)	2.2	5.9	8.1	1.2	5.1	13.4	1.8	7.9	14.4	15.0
	700–799	58 (15)	4.0	4.9	10.0	1.6	5.9	14.9	2.6	8.4	15.5	10.4
	800–899	57 (15)	1.1	5.4	7.9	1.8	3.7	12.1	1.5	8.7	11.1	10.6
	900–999	58 (15)	4.3	8.5	7.8	1.4	6.0	12.2	2.2	6.8	13.1	13.2
	>999	58 (14)	3.1	7.8	10.0	1.7	5.2	13.7	1.7	14.7	19.1	15.0
P-value for trend		0.5601	<0.0001	0.0261	<0.0001	0.1229	0.0013	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Reference Limit			>7.2 pg/mL	5.8 or 6.1 pg/mL*	>4.2 pg/mL	>3.3 pg/mL	>3.7 pg/mL	>124 or >449 pg/mL*	>25.2 ng/mL	<35 mg/dL	>0.9 μU/mL	5.9%