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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Trends Mol Med. 2017 Sep 5;23(10):874–898. doi: 10.1016/j.molmed.2017.08.003

Figure 3. Precision Oncology Workflow.

Figure 3

In this proposed precision oncology workflow, patient molecular profiles are used to suggest first-line (combination) therapies. Functional models serve to test safety and efficacy of selected drugs or screen for drugs in cases when molecular profiling is not informative. Patients are closely monitored during the course of therapy to detect resistance. Molecular profiling, computational analysis and functional testing of resistant tumors are repeated upon onset of resistance to determine second-line therapy options.