Table 3.
Cox regression analysis for incident ESRD according to baseline variables among 402 patients with kidney biopsies
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age, yr | 1.01 (0.99 to 1.03) | 0.23 | ||
| Sex | 1.50 (0.91 to 2.48) | 0.12 | ||
| Systolic BP, >140 mmHg | 1.03 (1.02 to 1.04) | <0.001 | 1.00 (0.99 to 1.02) | 0.68 |
| eGFR, ≥15 ml/min per 1.73 m2 | 0.96 (0.95 to 0.97) | <0.001 | 0.98 (0.97 to 0.99) | <0.001 |
| Disease type | <0.001 | <0.001 | ||
| IgAN | 1.0 (Reference) | 1.0 (Reference) | ||
| IMN | 0.54 (0.13 to 0.98) | 0.001 | 0.15 (0.03 to 0.70) | 0.02 |
| DN | 3.61 (1.75 to 5.42) | 0.001 | 3.13 (1.59 to 6.18) | 0.001 |
| Focal segmental GN | 3.32 (1.26 to 10.23) | 0.02 | 2.10 (0.56 to 7.85) | 0.27 |
| Serum albumin, g/dl | 1.02 (0.99 to 1.05) | 0.16 | ||
| Log10 urine protein | 3.36 (1.83 to 6.12) | <0.001 | 2.63 (1.36 to 6.45) | 0.002 |
| Log10 urinary fibrinogen to Cr | 2.72 (1.91 to 3.87) | <0.001 | 2.12 (1.31 to 3.26) | 0.003 |
| IFTA | 3.41 (2.47 to 4.72) | <0.001 | 1.76 (1.22 to 2.52) | 0.002 |
| Global sclerosis | 1.19 (1.00 to 1.43) | 0.06 | ||
| Segmental sclerosis | 1.10 (0.55 to 2.20) | 0.80 | ||
HR, hazard ratio; 95% CI, 95% confidence interval; IgAN, IgA nephropathy; IMN, idiopathic membranous nephropathy; DN, diabetic nephropathy; Cr, creatinine; IFTA, interstitial fibrosis and tubular atrophy.