Table 1.

Studies examining corticosteroid therapy in acute interstitial nephritis

Author, Yr (ref)	Sample size		Peak SCr, mg/dl		Final SCr, mg/dl		Follow-Up, Mo	Comment
	Steroid	No Steroid	Steroid	No Steroid	Steroid	No Steroid
Clarkson et al. 2004 (4)	26	16	7.9	6.1	1.6	1.6	12	Patients received steroids late after diagnosis (median delay >3 wk).
González et al. 2008 (5)	52	9	5.9	4.9	2.1	3.7	19	Steroid treated patients with complete recovery had shorter delay to steroids (13 d) as compared with those without complete recovery (34 d).
Raza et al. 2012 (7)	37	12	6.5	5.2	2.8	3.4	19	Improved GFR with steroid versus control (P<0.05). No difference in kidney outcomes on the basis of steroid timing.
Muriithi et al. 2014 (6)	83	12	3.0	4.5	1.4	1.5	6	Steroid-treated patients had superior kidney outcomes with early versus late steroid therapy.
Valluri et al. 2015 (8)	73	51	4.03	3.16	NR	NR	12	Worse kidney function in steroid-treated versus control at biopsy (SCr 4.2 versus 3.3 mg/dl). Steroid-treated patients had complete recovery (48%) versus control group (41%); final SCr not different at 1 yr.
Prendecki et al. 2016 (9)	158	29	20.5 ml/min (eGFR)	25 ml/min (eGFR)	43 ml/min (eGFR)	24 ml/min (eGFR)	24	Steroid-treated patient had better eGFR at 2 yr and less dialysis (5.1% versus 24.1%). Dose, duration, and time to steroid initiation were variable.

SCr, serum creatinine concentration; NR, not reported.