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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Lung Cancer. 2017 Aug 5;112:47–56. doi: 10.1016/j.lungcan.2017.08.001

Figure 1. Mig-6 expression was down-regulated in oncogenic Kras-induced (CCSPCreKrasG12D) mouse lung tumors.

Figure 1

(A) Representative immunofluorescent (IF) staining of Mig-6 in normal airways of LSL-KrasG12D mice and in hyperplastic lesions and adenomatous lesions of KrasG12D mice (3 months of age). Three control mice and six KrasG12D mice were used for IF staining and whole lungs were examined. One representative region for each group was chosen to present here. Regions in the white boxes were further magnified. (B) RT-qPCR analysis of Mig-6 mRNA levels in Laser Capture Micro-dissected normal airways from the control mice (LSL-KrasG12D) and hyperplastic lesions and adenomatous lesions from the lungs of KrasG12D mice. (*p<0.05 and **p<0.01 vs. normal airways) (3 months of age).