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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: Lung Cancer. 2017 Aug 5;112:47–56. doi: 10.1016/j.lungcan.2017.08.001

(A) Analysis of white blood cells (WBC), neutrophils, lymphocytes, and macrophages in the BALF of control, Mig-6^d/d, Kras^G12D, and Mig-6^d/dKras^G12D mice, *P<0.05. Three mice were used for each group. (B) RT-qPCR analysis of the expression of pro-inflammatory genes in the lungs of control, Mig-6^d/d, Kras^G12D, and Mig-6^d/dKras^G12D mice. * p<0.05, ** p<0.01 and *** p<0.001. (C) PAS staining of lungs of control, Mig-6^d/d, Kras^G12D, and Mig-6^d/dKras^G12D mice (2 months of ages). Arrows indicate metaplastic mucus cells in the bronchial epithelium. (D) RT-qPCR analysis of mRNA levels of Muc5ac in the lungs of mice (2 months of age). * p<0.05, ** p<0.01 and *** p<0.001.

(A) Analysis of white blood cells (WBC), neutrophils, lymphocytes, and macrophages in the BALF of control, Mig-6^d/d, Kras^G12D, and Mig-6^d/dKras^G12D mice, *P<0.05. Three mice were used for each group. (B) RT-qPCR analysis of the expression of pro-inflammatory genes in the lungs of control, Mig-6^d/d, Kras^G12D, and Mig-6^d/dKras^G12D mice. * p<0.05, ** p<0.01 and *** p<0.001. (C) PAS staining of lungs of control, Mig-6^d/d, Kras^G12D, and Mig-6^d/dKras^G12D mice (2 months of ages). Arrows indicate metaplastic mucus cells in the bronchial epithelium. (D) RT-qPCR analysis of mRNA levels of Muc5ac in the lungs of mice (2 months of age). * p<0.05, ** p<0.01 and *** p<0.001.