Fig 5. Evidence of mutational disruption network activity of MAPK8.

Interaction strengths involving JUN N-terminal Kinase (MAPK8) in the mutant UACC812 cell line are lower than in wild type cell lines. Interaction strengths were calculated as the normalized Granger coefficients derived in each cellular context. Each point is an interaction and points that appear above the line of equality (Y = X) indicate loss of function. Interaction strengths derived from all other interactions not involving MAPK8 are shown as the background (grey dots). Both the upstream and downstream interactions of MAPK8 (red) are significantly disrupted.