Table 2. Conformational alterations in the lengths of LPAR6 extra and intra cellular segments upon conotoxins binding at 20ns interval.
IC and EC denote intracellular and extracellular regions, respectively.
| IC1 | EC1 | IC2 | EC2 | IC3 | EC3 | |
|---|---|---|---|---|---|---|
| Apo-LPAR6 | Ile41- Tyr55 | Phe75- Asp86 | Ile110- Val136 | Ser66- Thr179 | Cys203- Ile231 | Tyr250- Tyr271 |
| LPAR6-contryphan-R | Cys44- Tyr53 | Pro71- Lys90 | Asp113- Asn132 | Pro150- Ile184 | Val207- Leu228 | Leu249- Tyr276 |
| LPAR6-BuIA | Cys44- Glu51 | Pro70- Met94 | Arg114- Arg131 | Ala149- Val185 | Met206- Lys229 | Asn248- Ile275 |
| LPAR6-contryphan-Lo | Val45- Tyr52 | Pro71-Val93 | Asp113- Arg131 | Ala149- Arg183 | Val207- Leu228 | Asn248- Leu277 |