Table 1. Clinical and biochemical characteristics of controls and hypertriglyceridemic patients.
| Controls (n = 1,549) | Cases (n = 599) | pa | pb | |||
|---|---|---|---|---|---|---|
| Age (year) | 49.1 | ±0.29 | 50.8 | ±0.45 | 0.002 | - |
| Male/Female, n (%) | 564 (36.4)/985 (63.6) | 300 (50.1)/299 (49.9) | <0.001 | - | ||
| BMI (kg/m2) | 23.7 | ±0.08 | 25.3 | ±0.12 | <0.001 | - |
| Current smoker, n (%) | 204 (13.2) | 121 (20.2) | <0.001 | - | ||
| Current drinker, n (%) | 920 (59.5) | 372 (62.3) | 0.241 | - | ||
| Systolic BP (mmHg) | 120.4 | ±0.0 | 126.0 | ±0.63 | <0.001 | 0.001 |
| Diastolic BP (mmHg) | 75.0 | ±0.28 | 80.1 | ±0.44 | <0.001 | <0.001 |
| Triglyceride (mg/dL)∮ | 89.5 | ±0.79 | 223.4 | ±3.34 | <0.001 | <0.001 |
| Total cholesterol (mg/dL)∮ | 193.9 | ±0.89 | 208.9 | ±1.50 | <0.001 | <0.001 |
| HDL cholesterol (mg/dL)∮ | 55.6 | ±0.34 | 46.2 | ±0.45 | <0.001 | <0.001 |
| LDL cholesterol (mg/dL)∮ | 120.6 | ±0.81 | 120.2 | ±1.46 | 0.413 | 0.022 |
| Glucose (mg/dL)∮ | 96.6 | ±0.55 | 100.6 | ±0.96 | <0.001 | 0.346 |
| Apolipoprotein A5 (ng/mL)∮ | 287.0 | ±6.94 | 229.2 | ±8.87 | <0.001 | <0.001 |
| LDL particle size (nm)∮ | 24.1 | ±0.02 | 23.4 | ±0.08 | <0.001 | <0.001 |
| Oxidized LDL (U/L)∮ | 45.6 | ±0.55 | 48.9 | ±0.84 | <0.001 | 0.003 |
| Malondialdehyde (nmol/mL)∮ | 8.97 | ±0.11 | 9.57 | ±0.17 | <0.001 | 0.081 |
| ba-PWV (cm/s)∮ | 1,300.7 | ±7.71 | 1,371.3 | ±16.9 | <0.001 | 0.149 |
| APOA5 -1131T>C, n (%) | ||||||
| TT | 807 (52.1) | 214 (35.7) | <0.001 | |||
| TC | 648 (41.8) | 286 (47.7) | ||||
| CC | 94 (6.1) | 99 (16.5) | ||||
| C allele frequency | 836 (27.0) | 484 (40.4) | <0.001 | |||
| APOA5 c.553 G>T, n (%) | ||||||
| GG | 1,335 (86.2) | 464 (77.5) | <0.001 | |||
| GT | 210 (13.6) | 128 (21.4) | ||||
| TT | 4 (0.3) | 7 (1.2) | ||||
| T allele frequency | 218 (7.0) | 142 (11.9) | <0.001 | |||
Means ± standard errors (SE).
∮Tested using logarithmic transformation.
p-values were derived from an independent t-test.
pa, Unadjusted;
pb, Adjusted for age, sex, BMI, smoking, and drinking.