Table 3.
Correlations Between Placental Membrane DHA Levels and Placental Cellular Signaling and Nutrient Transport Capacity
| Characteristic | Spearman R Value | P Value | FDR |
|---|---|---|---|
| Amino acid transporter expression | |||
| LAT1 (MVM) | −0.636 | 0.0001 | 0.01 |
| Inflammation | |||
| IκBα | −0.488 | 0.003 | 0.04 |
| COX-2 | 0.463 | 0.01 | 0.05 |
| p38α (total) | −0.389 | 0.02 | 0.10 |
| NF-κB p65 activation | 0.328 | 0.05 | 0.17 |
| p38α (phospho; T180/Y182) | −0.322 | 0.06 | 0.17 |
| Insulin signaling | |||
| IRS1 (total) | −0.404 | 0.02 | 0.10 |
| GRB2 | −0.385 | 0.02 | 0.10 |
| AMPK (total) | −0.359 | 0.03 | 0.13 |
| ERK (total) | 0.342 | 0.04 | 0.16 |
| AKT (total) | 0.310 | 0.07 | 0.19 |
| STAT signaling | |||
| STAT5 (total) | −0.525 | 0.001 | 0.02 |
| mTOR signaling | |||
| mTOR (total) | −0.403 | 0.02 | 0.10 |
Abbreviations: AMPK, AMP-activated protein kinase; COX-2, cyclooxygenase 2; ERK, extracellular signal-regulated kinase; FDR, false discovery rate; IRS1, insulin receptor substrate 1.