Table 3.
ceBMI Above Obesity Threshold Influences Progression of Type 1 Diabetes in Specific Subsets of Adults in the PTP Cohort
| Sex and Age | ceBMI | Participants (n) | HRa (95% CI) | P Value |
|---|---|---|---|---|
| Male | ||||
| ≥35 y | <5 | 89 | Reference | |
| ≥5 | 60 | 3.63 (0.94–14.1) | 0.062 | |
| <35 y | <5 | 51 | 5.31 (1.4–20.2) | 0.014 |
| ≥5 | 18 | 3.38 (0.68–17.0) | 0.14 | |
| Female | ||||
| ≥35 y | <5 | 208 | Reference | |
| ≥5 | 82 | 0.69 (0.22–2.2) | 0.54 | |
| <35 y | <5 | 110 | 1.38 (0.53–3.59) | 0.51 |
| ≥5 | 45 | 4.7 (1.67–13.2) | 0.003 |
a
Models adjusted for antibody status (one positive autoantibody vs two or more positive autoantibodies at the first BMI evaluation) in women. Models did not adjust for any factors (i.e., no adjustment for antibody status) in men because of to the greater limitations of numbers of events in that subgroup. Abbreviation: CI, confidence interval.