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. 2017 Sep 28;102(12):4568–4577. doi: 10.1210/jc.2017-01411

Table 2.

Anthropometric and Laboratory Measurements at Baseline and 3, 6, 9, and 12 Months After rhIGF-1 Pilot Trial

Study Visit Age, y Height, cm (SDS) HV, cm/y (SDS) BMI, kg/m2 (SDS) Bone Age, y Test. Vol., mL Total IGF-1, ng/mL Free IGF-1, µg/L PAPP-A2, µg/L IGFBP-3, ng/mL ALS, mg/L GH, ng/mL
P3a baseline 10.4 122 (−2.9) 3 (−2.8) 14 (−1.5) 9 3 546.8 0.79 0.11 >10,000 18 0.2
3 mob 10.7 123.1 (−2.8) 14.7 (−1.4) 3 524.0 0.35 0.133 >10,000 22 0.8
6 mo 11 125.7 (−2.6) 15.7 (−0.7) 3 688.9 1.05 0.176 6141 14 0.1
9 mo 11.2 127 (−2.5) 16 (−0.6) 3 739.2 1.67 0.157 6492 11 0.1
12 mo 11.4 128.2 (−2.5) 6.2 (+1.2) 16.4 (−0.5) 10 3 709.1 1.17 0.19 6362 14 0.1
P2 baseline 14.5 142.4 (−2.9) 4.3 (−1.6) 27 (+1.7) 13.5 6 573.2 5.59 0.064 8997 23 0.1
3 mo 14.8 143.5 (−2.9) 27 (+1.7) 656.3 5.93 0.088 >10,000 24 0.1
12 mo 15.5 147.2 (−3.0) 4.8 (+1.5) 27 (+1.7) 14.5 12 756.2 6.07 0.135 8983 17 0.1

Reference values for P3 (10-year-old boy): Total IGF-1, 104–430 ng/mL; IGFBP-3, 2343–5879 ng/mL; ALS, 5.6–16 mg/L.

Reference values for P2 (14-year-old boy): Total IGF-1, 150–554 ng/mL; IGFBP-3, 2599–6294 ng/mL; ALS, 5.6–16 mg/L.

Reference values for PAPP-A2: Tanner I, 0.16–2.69 µg/L; Tanner V, 0.23–0.80 µg/L.

Reference values for free IGF-1: Tanner I, 1.58–3.15 µg/L; Tanner V, 4.89–9.37 µg/L.

Abbreviations: BMI, body mass index; HV, height velocity; Test. Vol., testicular volume.

a

P3 was treated with rhIGF-1.

b

P3 was not receiving rhIGF-1 treatment at the time of the study visit.