Table 3.

Bone Density and Body Composition at Baseline and 12 Months

	Baseline			12 mo		Change
	P1	P2	P3a	P2	P3a	P2	P3
DXA
Age, y	19	14	10	15	11
Height SDS	−3.8	−2.9	−2.9	−3.0	−2.5	−1	+0.4
Whole body minus head
BMD, g/cm2	0.764	0.652	0.569	0.716	0.646	9.9%	13.6%
z Score	−2.9	−3.6	−2.5	−3.2	−1.8	+0.4	+0.7
HA z score	−0.5	−2.5	−0.7	−2.2	−0.1	+0.3	+0.6
Lumbar spine
BMD, g/cm2	0.749	0.504	0.497	0.531	0.561	5.4%	12.9%
z Score	−2.7	−3.2	−1.6	−3.9	−1.0	−0.7	+0.6
HA z score	−1	−1.3	−0.1	−1.9	0.3	−0.6	+0.4
Total hip
BMD, g/cm2	0.726	0.567	0.593	0.600	0.629	5.9%	6.1%
z Score	−1.8	−3.8	−2.1	−3.5	−2.0	+0.3	+0.1
HA z score	−0.03	−1.6	−0.5	−2.0	−0.4	−0.4	+0.1
Forearm
BMD, g/cm2	0.627	0.499	0.448	0.538	0.486	7.6%	8.5%
z Score	−1.1	−2.8	−1.9	−2.8	−1.3	0	+0.6
HA z score	0	−1.7	−0.5	−1.8	0	−0.1	+0.5
Total lean body mass, g	23092	27286	15274	32964	18961	20.8%	24.1%
Total fat mass, g	17809	27380	6543	26969	7390	−1.5%	12.9%
Total body fat %	42.3	49.2	29	44.2	27.1	−5	−1.9
Bone markers
C-telopeptides, ng/mL	726	1974	1744	1855	2262	−6%	29%
Osteocalcin, ng/mL	28	101	86	138	123	38%	43%

Abbreviation: HA, height-adjusted.

^aPatient treated with rhIGF-1.