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. 2017 Sep 13;102(12):4435–4447. doi: 10.1210/jc.2016-3716

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This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 5. — CTGF and GPER expression correlates in human CRC. (A) Immunoblotting of GPER and CTGF expression in normal (N) and cancerous (C) human colon tissue. β-Actin was used as a loading control. One representative blot from three independent experiments. (B) GPER and CTGF expression were increased in human CRC, as measured by the immunoblotting relative intensity to β-actin. *P < 0.05, ***P < 0.001 (two-tailed Student t test used; n = 17). (C) Correlation between GPER and CTGF relative intensity in normal and cancerous human colon tissue (n = 17). (D) Schematic diagram showing proposed pathway through which estrogens act, via GPER, to augment proliferation in CRC.