Table 2.
IR per 1000 Person-Years and HR of Hospitalization With Infection: the Atherosclerosis Risk in Communities Study, 1990 to 2013
| Variable | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 |
|---|---|---|---|---|
| FGF23, pg/mL | ||||
| Range | <33.8 | 33.8–41.7 | 41.7–51.4 | ≥51.4 |
| Events/persons | 1206/2802 | 1191/2808 | 1296/2816 | 1385/2792 |
| Crude IR per 1000 person-years | 26.1 (24.6–27.6) | 25.4 (24.0–26.9) | 28.1 (26.6–29.6) | 32.1 (30.5–33.9) |
| Age-, sex-, and race-adjusted HR | 1.04 (0.96–1.13) | 1 (Reference) | 1.09 (1.01–1.18) | 1.24 (1.15–1.34) |
| Fully adjusted HR | 1.03 (0.95–1.11) | 1 (Reference) | 1.04 (0.96–1.13) | 1.12 (1.03–1.21) |
| 25(OH)D, ng/mL | ||||
| Range | <18.5 | 18.5–23.8 | 23.8–29.6 | ≥29.6 |
| Events/persons | 1318/2768 | 1245/2779 | 1311/2835 | 1204/2836 |
| Crude IR per 1000 person-years | 30.3 (28.7–32.0) | 27.5 (26.0–29.0) | 28.3 (26.8–29.9) | 25.4 (24.0–26.9) |
| Age-, sex-, and race-adjusted HR | 1.18 (1.09–1.28) | 1 (Reference) | 1.02 (0.94–1.10) | 0.89 (0.82–0.97) |
| Fully adjusted HR | 1.11 (1.03–1.21) | 1 (Reference) | 1.04 (0.96–1.12) | 0.93 (0.86–1.01) |
| PTH, pg/mL | ||||
| Range | <31.2 | 31.2–39.2 | 39.2–49.1 | ≥49.1 |
| Events/persons | 1240/2785 | 1218/2811 | 1265/2836 | 1355/2786 |
| Crude IR per 1000 person-years | 27.5 (26.0–29.1) | 26.0 (24.6–27.5) | 27.2 (25.7–28.7) | 30.8 (29.2–32.4) |
| Age-, sex-, and race-adjusted HR | 1.09 (1.00–1.18) | 1 (Reference) | 1.03 (0.96–1.12) | 1.15 (1.07–1.25) |
| Fully adjusted HR | 1.07 (0.99–1.16) | 1 (Reference) | 1.02 (0.94–1.10) | 1.09 (1.01–1.18) |
| Corrected calcium, mg/dL | ||||
| Range | <9.1 | 9.1–9.4 | 9.4–9.6 | ≥9.6 |
| Events/persons | 988/2281 | 1417/3209 | 989/2214 | 1684/3514 |
| Crude IR per 1000 person-years | 26.1 (24.5–27.8) | 26.9 (25.5–28.3) | 26.9 (25.3–28.7) | 30.5 (29.1–32.0) |
| Age-, sex-, and race-adjusted HR | 1.00 (0.92–1.08) | 1 (Reference) | 0.99 (0.91–1.08) | 1.11 (1.04–1.19) |
| Fully adjusted HR | 1.02 (0.94–1.11) | 1 (Reference) | 1.00 (0.92–1.09) | 1.11 (1.03–1.20) |
| Phosphorus, mg/dL | ||||
| Range | <3.2 | 3.2–3.5 | 3.5–3.8 | ≥3.8 |
| Events/persons | 1135/2392 | 1153/2585 | 1512/3456 | 1278/2785 |
| Crude IR per 1000 person-years | 29.7 (28.1–31.5) | 27.8 (26.2–29.4) | 26.4 (25.1–27.7) | 28.2 (26.7–29.7) |
| Age-, sex-, and race-adjusted HR | 1.04 (0.96–1.13) | 1 (Reference) | 0.95 (0.88–1.02) | 1.04 (0.96–1.13) |
| Fully adjusted HR | 1.02 (0.94–1.11) | 1 (Reference) | 0.98 (0.90–1.05) | 1.05 (0.97–1.14) |
Data in parentheses are interquartile ranges.
Fully adjusted models adjusted for age, sex, race, body mass index, smoking, alcohol consumption, years of education, serum albumin, and hsCRP, medication use (vitamin D, calcium, steroids, and antineoplastic agents), diabetes, hypertension, history of cancer, COPD, coronary heart disease, stroke, and eGFR. The levels of 25(OH)D were adjusted to account for seasonality. Corrected calcium (mg/dL) = serum calcium (mg/dL) + 0.8 × (4.0 − serum albumin in g/dL) if serum albumin <4.0 g/dL.