Skip to main content
. 2017 Sep 27;102(12):4648–4657. doi: 10.1210/jc.2017-01868

Table 3.

HR of Infection-Related Mortality: the Atherosclerosis Risk in Communities Study, 1990 to 2013

Variable Quartile 1 Quartile 2 Quartile 3 Quartile 4
FGF23, pg/mL
 Range <33.8 33.8–41.7 41.7–51.4 ≥51.4
 Deaths/persons 219/2802 204/2808 256/2816 306/2792
 Mortality rate per 1000 person-years 4.0 (3.5–4.6) 3.7 (3.2–4.3) 4.7 (4.1–5.3) 5.9 (5.2–6.6)
 Age-, sex-, and race-adjusted HR 1.12 (0.92–1.35) 1 (Reference) 1.21 (1.01–1.46) 1.48 (1.24–1.77)
 Fully adjusted HR 1.08 (0.89–1.31) 1 (Reference) 1.16 (0.96–1.39) 1.25 (1.04–1.50)
25(OH)D, ng/mL
 Range <18.5 18.5–23.8 23.8–29.6 ≥29.6
 Deaths/persons 284/2768 222/2779 243/2835 236/2836
 Mortality rate per 1000 person-years 5.5 (4.9–6.2) 4.1 (3.6–4.7) 4.4 (3.9–5.0) 4.2 (3.7–4.8)
 Age-, sex-, and race-adjusted HR 1.51 (1.26–1.80) 1 (Reference) 1.03 (0.86–1.24) 0.96 (0.80–1.16)
 Fully adjusted HR 1.36 (1.14–1.63) 1 (Reference) 1.03 (0.86–1.24) 0.95 (0.79–1.15)
PTH, pg/mL
 Range <31.2 31.2–39.2 39.2–49.1 ≥49.1
 Deaths/persons 245/2785 234/2811 256/2836 250/2786
 Mortality rate per 1000 person-years 4.6 (4.1–5.2) 4.2 (3.7–4.8) 4.7 (4.1–5.3) 4.7 (4.1–5.3)
 Age-, sex-, and race-adjusted HR 1.15 (0.96–1.38) 1 (Reference) 1.09 (0.91–1.30) 1.03 (0.86–1.24)
 Fully adjusted HR 1.12 (0.93–1.34) 1 (Reference) 1.08 (0.90–1.29) 0.97 (0.81–1.16)
Corrected calcium (mg/dL)
 Range <9.1 9.1–9.4 9.4–9.6 ≥9.6
 Deaths/persons 172/2281 268/3209 189/2214 356/3514
 Mortality rate per 1000 person-years 3.9 (3.3–4.5) 4.3 (3.8–4.9) 4.4 (3.8–5.1) 5.3 (4.8–5.9)
 Age-, sex-, and race-adjusted HR 0.94 (0.77–1.14) 1 (Reference) 1.01 (0.84–1.22) 1.21 (1.03–1.42)
 Fully adjusted HR 0.96 (0.80–1.17) 1 (Reference) 1.04 (0.86–1.25) 1.20 (1.02–1.42)
Phosphorus, mg/dL
 Range <3.2 3.2–3.5 3.5–3.8 ≥3.8
 Deaths/persons 218/2392 240/2585 281/3456 246/2785
 Mortality rate per 1000 person-years 4.8 (4.2–5.4) 4.9 (4.3–5.5) 4.2 (3.7–4.7) 4.6 (4.0–5.2)
 Age-, sex-, and race-adjusted HR 0.90 (0.75–1.08) 1 (Reference) 0.90 (0.76–1.07) 1.04 (0.87–1.26)
 Fully adjusted HR 0.86 (0.72–1.04) 1 (Reference) 0.94 (0.79–1.12) 1.04 (0.86–1.25)

Analysis was based on 985 infection-related deaths, defined as death occurring during or within 30 days of hospitalization with infection. Fully adjusted models adjusted for age, sex, race, body mass index, smoking, alcohol consumption, years of education, serum albumin, hsCRP, medication use (vitamin D, calcium, steroids, and antineoplastic agents), diabetes, hypertension, history of cancer, COPD, coronary heart disease, stroke, and eGFR. Levels of 25(OH)D were adjusted to account for seasonality. Corrected calcium (mg/dL) = serum calcium (mg/dL) + 0.8 × (4.0 − serum albumin in g/dL) if serum albumin <4.0 g/dL.