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. 2017 Oct 23;18(12):984–989. doi: 10.1080/15384047.2017.1385683

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Figure 7. — Cleaved caspase 3, Bax and Bcl-2 proteins validated by western blot, in A549 and A549/DDP (A, B), and SKOV3 and SKOV3/DDP (C, D) cells. In 4 cell lines, caspase 3 and Bax were increased and Bcl-2 decreased, in groups PDT and PDT + DDP, demonstrating the occurrence of apoptosis. However, Bcl-2/Bax/caspase 3 was not altered in group DDP, in A549/DDP and SKOV3/DDP cells, indicating the malfunction of apoptosis. Data were mean ± standard deviation for 3 independent experiments. *: vs. group Ctrl, p < 0.05; &: vs. group DDP, p < 0.05; #: vs. group PDT, p < 0.05.