Table 3.

Relationship between estradiol, estrone, insulin, and endometrial cancer risk after stratification for BMI, WHR, diabetes, or hypertension using a logistic regression model in total, premenopausal and postmenopausal women, respectively.

		Estrone			Estradiol			Insulin
		OR	95% CI	P value	OR	95% CI	P value	OR	95% CI	P value
Total women	BMI
	<24	1.487	0.972–2.273	0.067	1.032	0.675–1.577	0.885	2.748	1.706–4.427	0.000
	≥24	2.406	1.748–3.312	0.000	0.896	0.655–1.224	0.489	2.304	1.660–3.196	0.000
	WHR
	<0.85	1.130	0.661–1.931	0.655	0.616	0.357–1.064	0.083	2.921	1.621–5.265	0.000
	≥0.85	2.504	1.856–3.378	0.000	1.088	0.813–1.456	0.571	2.219	1.578–2.872	0.000
	Diabetes
	No	2.006	1.521–2.644	0.000	0.891	0.679–1.170	0.407	2.581	1.951–3.414	0.000
	Yes	2.718	1.219–6.060	0.015	2.057	0.936–4.524	0.073	1.851	0.823–4.165	0.137
	Hypertension
	No	1.837	1.342–2.515	0.000	1.045	0.766–1.426	0.779	2.918	2.112–4.032	0.000
	Yes	2.669	1.690–4.215	0.000	0.985	0.634–1.532	0.947	1.683	1.059–2.675	0.028
Premenopausal women	BMI
	<24	1.549	0.697–3.445	0.283	0.83	0.376–1.830	0.644	3.5	1.468–8.343	0.005
	≥24	0.967	0.544–1.718	0.908	0.541	0.303–0.968	0.038	2.571	1.392–4.746	0.003
	WHR
	<0.85	0.771	0.287–2.077	0.608	0.727	0.269–1.965	0.53	2.756	0.973–7.810	0.056
	≥0.85	1.258	0.724–2.186	0.415	0.588	0.337–1.024	0.061	2.806	1.580–4.983	0.000
	Diabetes
	No	0.94	0.576–1.532	0.803	0.537	0.327–0.881	0.014	3.778	2.255–6.328	0.000
	Yes	1.939E8	–	0.998	1.419	0.121–16.644	0.780	5.571	0.468–66.325	0.174
	Hypertension
	No	1.276	0.764–2.129	0.352	0.518	0.309–0.868	0.013	4.76	2.754–8.227	0.000
	Yes	0.917	0.322–2.612	0.871	0.794	0.281–2.238	0.662	1.167	0.381–3.573	0.786
Postmenopausal women	BMI
	<24	1.613	0.960–2.710	0.071	0.989	0.589–1.661	0.968	2.429	1.371–4.305	0.002
	≥24	2.401	1.640–3.516	0.000	0.769	0.529–1.119	0.170	2.096	1.424–3.086	0.000
	WHR
	<0.85	1.341	0.697–2.583	0.380	0.706	0.362–1.376	0.307	3.253	1.545–6.849	0.002
	≥0.85	2.426	1.705–3.452	0.000	0.876	0.620-1.236	0.45	1.837	1.293–2.609	0.001
	Diabetes
	No	2.282	1.632–3.193	0.000	0.875	0.630–1.216	0.428	2.11	1.509–2.950	0.000
	Yes	1.535	0.662–3.558	0.318	1.071	0.464–2.475	0.872	1.842	0.739–4.589	0.190
	Hypertension
	No	1.738	1.168–2.586	0.006	0.782	0.527–1.160	0.222	2.188	1.459–3.281	0.000
	Yes	2.357	1.424–3.900	0.001	0.912	0.557–1.495	0.715	1.751	1.048–2.925	0.032

The cut-off points for serum estradiol concentrations were 21.01, 50.18, and 18.36 pg/mL in total, premenopausal, and postmenopausal women, respectively.

The cut-off points for serum estrone concentrations were 42.70, 58.53, and 37.51 pg/mL in total, premenopausal, and postmenopausal women, respectively.

The cut-off points for serum insulin concentrations were 8.82, 8.74, and 8.90 mIU/mL in total, premenopausal, and postmenopausal women, respectively.

CI, confidence interval; OR, odds ratio; BMI, body mass index; WHR, waist-to-hip ratio.

Red text: Statistically significant.