Table 2.
The neutralizing antibody breadth induced by various gp120 DNA vaccine prime in rabbits.
| Envelope | Subtype | No. of PV neutralized | % of PV neutralized |
|---|---|---|---|
| WITO4561 | B | 1 | 6% |
| NA420-B42 | B | 2 | 13% |
| QH0515.01 | B | 2 | 13% |
| PVO-04 | B | 2 | 13% |
| REJ4541.67 | B | 2 | 13% |
| TRO.11 | B | 2 | 13% |
| TRJO4551 | B | 2 | 13% |
| THRO4156 | B | 2 | 13% |
| ADA | B | 3 | 19% |
| NA420-LN85 | B | 3 | 19% |
| NA118-B12 | B | 3 | 19% |
| P6B33 | B | 3 | 19% |
| QH0692.42 | B | 3 | 19% |
| BG1168.01 | B | 3 | 19% |
| Yu-2 | B | 3 | 19% |
| Ba-L | B | 3 | 19% |
| H78639 | B | 3 | 19% |
| AD8 | B | 4 | 25% |
| AC10.0.29 | B | 4 | 25% |
| 89.6 | B | 5 | 31% |
| RHPA4259 | B | 5 | 31% |
| CAAN5352 | B | 5 | 31% |
| SC422661.8 | B | 5 | 31% |
| SF162 | B | 5 | 31% |
| 5768.04 | B | 6 | 38% |
| SS1196.01 | B | 6 | 38% |
| NA420-LN40 | B | 6 | 38% |
| 92US715.6 | B | 8 | 50% |
| NA118-LN27 | B | 9 | 56% |
| AC10.44 | B | 9 | 56% |
| 6535.3 | B | 10 | 63% |
| NA20-B59 | B | 11 | 69% |
| 6101LN | B | 12 | 75% |
| NA20-B27 | B | 13 | 81% |
| NA20-B76 | B | 14 | 88% |
| JR-FL | B | 14 | 88% |
| 92RW020.5 | A | 1 | 6% |
| CA1 | A | 2 | 13% |
| 92UG037.8 | A | 7 | 44% |
| Du123-06 | C | 2 | 13% |
| 92BR025.9 | C | 2 | 13% |
| 96ZM651.2 | C | 2 | 13% |
| ZM53M.PB12 | C | 2 | 13% |
| ZM135M.PL10a | C | 2 | 13% |
| ZM233M.PB6 | C | 2 | 13% |
| Du156-12 | C | 3 | 19% |
| 96BW01B22 | C | 3 | 19% |
| 96BW15C02 | C | 3 | 19% |
| DU422.1 | C | 3 | 19% |
| ZM214M.PL15 | C | 3 | 19% |
| ZM109F.PB4 | C | 3 | 19% |
| CAP210.2 | C | 3 | 19% |
| ZM197M.PB7 | C | 3 | 19% |
| ZM249M.PL1 | C | 3 | 19% |
| CAP45.2 | C | 4 | 25% |
| DU172.17 | C | 4 | 25% |
| 93MW965.26 | C | 15 | 94% |
| 92UG021.16 | D | 14 | 88% |
| 93TH976.17 | A/E | 2 | 13% |
| AE-cons | A/E | 8 | 50% |
| 93BR020.17 | F1 | 7 | 44% |
| 92UG975.10 | G | 3 | 19% |
This panel of pseudoviruses (PV) included three TCLA strains (MN, NL43 and SF162), and 13 primary isolates from subtype A (92RW020, 94UG103), B (AC10.0.29, PVO.4, QH0692.42, SC422661.8, JRCSF), C (93IN905, 98CN006), D (92UG046, 94UG114), and AE (92TH021, CMU02). Based on the % PV neutralized, there are three subgroups: the red highlighted (12 gp120 immunogens, 19%) is the subgroup with broad NAb (>= 50% of PV neutralized: the yellow highlight (10 gp120 immunogens, 16%) is the subgroup with moderate NAb (25–49% of PV neutralized); and remaining (40 gp120 immunogens, 65%) is the subgroup with narrow NAb (< 24% of PV neutralized).